Publication Trends in Exosomes Nanoparticles for Cancer Detection

International Journal of Nanomedicine, vol. 15, pp. 4453–4470, 2020

18 Pages Posted: 26 Apr 2021

See all articles by Saba Ale Ebrahim

Saba Ale Ebrahim

Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran

Amirhossein Ashtari

Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran

Maysam Zamani Pedram

Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran

Nader Ale Ebrahim

Centre for Research Services, Institute of Management and Research Services (IPPP), University of Malaya (UM); University of Malaya (UM) - Department of Engineering Design and Manufacture

Amir Sanati Nezhad

University of Calgary - BioMEMS and Bioinspired Microfluidic Laboratory

Date Written: May 2, 2020

Abstract

Background: Exosomes are small vesicles produced by almost all cells in the body and found in all biofluids. Cancer cell-derived exosomes are known to have distinct, measurable signatures, applicable for early cancer diagnosis. Despite the present bibliometric studies on “Cancer detection” and “Nanoparticles”, no single study exists to deal with “Exosome” bibliometric study.

Methods: This bibliometric work investigated the publication trends of “Exosomes” nanoparticles and its application in cancer detection, for the literature from 2008 to July 2019. The data were collected from the Web of Science Core Collection. There were variant visual maps generated to show annual publication, most- relevant authors, sources, countries, topics and keywords. The network analysis of these studies was investigated to evaluate the research trends in the field of exosomes. In addition, the data were qualitatively analyzed according to 22 top-cited articles, illustrating the frequently used subjects and methods in exosomes research area.

Results: The results showed that the documents in this field have improved the citation rate. The top-relevant papers are mostly published in Scientific Reports journal which has lost its popularity after 2017, while today, Analytical Chemistry is leading in publishing the most articles related to exosomes. The documents containing keywords of plasma, cells, cancer, biomarkers, and vesicles as keywords plus, are more likely to be published in PLoS One journal. The clustering of the keywords network showed that the keyword theme of “extracellular vesicles” has the highest centrality rate. In global research, USA is the most corresponding country, followed by China, Korea and Australia. Based on the qualitative analysis, the published documents with at least 50 citations have used exosome release, cargo, detection, purification and secretion, as their targets and applied cell culture or isolation as their methods.

Conclusion: The bibliometric study on exosomes nanoparticles for cancer detection provides a clear vision of the future research direction and identifies the potential opportunities and challenges. This may lead new researchers to select the proper subfields in exosome-related research fields.

Keywords: exosomes, cancer detection, nanoparticles, microvesicles, bibliometrics, research productivity

JEL Classification: L11, L1, L2, M11, M12, M1, M54, Q1, O1, O3, P42, P24, P29, Q31, Q32, L17

Suggested Citation

Ale Ebrahim, Saba and Ashtari, Amirhossein and Zamani Pedram, Maysam and Ale Ebrahim, Nader and Nezhad, Amir Sanati, Publication Trends in Exosomes Nanoparticles for Cancer Detection (May 2, 2020). International Journal of Nanomedicine, vol. 15, pp. 4453–4470, 2020, Available at SSRN: https://ssrn.com/abstract=3826786

Saba Ale Ebrahim

Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran ( email )

No.24, Agaahi Alley, Dabestan St.
Seyed-khandan, Resalat Highway, POB: 16315-989
Tehran, Tehran 16315-989
Iran

Amirhossein Ashtari

Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran ( email )

No.24, Agaahi Alley, Dabestan St.
Seyed-khandan, Resalat Highway, POB: 16315-989
Tehran, Tehran 16315-989
Iran

Maysam Zamani Pedram

Faculty of Electrical Engineering, K.N. Toosi University of Technology, Tehran, Iran ( email )

No.24, Agaahi Alley, Dabestan St.
Seyed-khandan, Resalat Highway, POB: 16315-989
Tehran, Tehran 16315-989
Iran

Nader Ale Ebrahim (Contact Author)

Centre for Research Services, Institute of Management and Research Services (IPPP), University of Malaya (UM) ( email )

Kuala Lumpur, Wilayah Persekutuan 50603
University of Malaya (UM)
Kuala Lumpur, Wilayah Persekutuan 50603
Malaysia

HOME PAGE: http://https://umresearch.um.edu.my/

University of Malaya (UM) - Department of Engineering Design and Manufacture ( email )

Kuala Lumpur, 50603
Malaysia

Amir Sanati Nezhad

University of Calgary - BioMEMS and Bioinspired Microfluidic Laboratory ( email )

Calgary, T2N 1N4
Canada

Do you have a job opening that you would like to promote on SSRN?

Paper statistics

Downloads
9
Abstract Views
134
PlumX Metrics